We estimated copy number profiles from scRNA-seq data for AML samples, using a matched cell type approach with HCA
as a reference to infer the copy number baseline. This approach allowed us to identify clusters with cytogenetic
abnormalities. For each sample, we generated one clustered heatmap and two UMAP representations.
The clustered heatmap represents the scRNA-seq copy number profiles. Each row corresponds to a cell,
color-coded and ordered according to its Phenograph cluster, and each column corresponds to an ordered genomic region.
The black and gray boxes indicate the chromosomes (left: chromosome 1 -> right: chromosome X). The blue signal
indicates a loss, while the red signal indicates a gain.
The first UMAP corresponds to the sample's scRNA-seq data, colored by Phenograph cluster, while the second
UMAP corresponds to the cell type annotation V2.2 predicted using our random forest classifier trained on HCA data.
IMPORTANT: Please note that the data displayed on this website is not for diagnostic purposes and is not a substitute for a doctor's advice.
Please consult your doctor with any questions. The information provided here is only for informational and educational purposes.